Invention Grant
US08946172B2 Method for reducing scarring during wound healing using antisense compounds directed to CTGF
有权
使用针对CTGF的反义化合物在伤口愈合过程中减少瘢痕形成的方法
- Patent Title: Method for reducing scarring during wound healing using antisense compounds directed to CTGF
- Patent Title (中): 使用针对CTGF的反义化合物在伤口愈合过程中减少瘢痕形成的方法
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Application No.: US12547481Application Date: 2009-08-26
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Publication No.: US08946172B2Publication Date: 2015-02-03
- Inventor: Thomas A. Mustoe , Nicholas M. Dean , Mark Sisco , Zol Kryger , C. Frank Bennett
- Applicant: Thomas A. Mustoe , Nicholas M. Dean , Mark Sisco , Zol Kryger , C. Frank Bennett
- Applicant Address: US NY New York US CA Carlsbad US IL Evanston
- Assignee: Excaliard Pharmaceuticals, Inc.,Isis Pharmaceuticals, Inc.,Northwestern University
- Current Assignee: Excaliard Pharmaceuticals, Inc.,Isis Pharmaceuticals, Inc.,Northwestern University
- Current Assignee Address: US NY New York US CA Carlsbad US IL Evanston
- Agency: Lando & Anastasi LLP
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C07H21/04
Abstract:
This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.
Public/Granted literature
- US20110054004A1 METHOD FOR REDUCING SCARRING DURING WOUND HEALING USING ANTISENSE COMPOUNDS DIRECTED TO CTGF Public/Granted day:2011-03-03
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