Invention Grant
US08946182B2 Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
有权
通过抑制RNASE H1的天然反义转录物治疗RNASE H1相关疾病
- Patent Title: Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1
- Patent Title (中): 通过抑制RNASE H1的天然反义转录物治疗RNASE H1相关疾病
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Application No.: US13575206Application Date: 2011-01-25
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Publication No.: US08946182B2Publication Date: 2015-02-03
- Inventor: Joseph Collard , Olga Khorkova Sherman
- Applicant: Joseph Collard , Olga Khorkova Sherman
- Applicant Address: US FL Miami
- Assignee: CuRNA, Inc.
- Current Assignee: CuRNA, Inc.
- Current Assignee Address: US FL Miami
- Agency: CuRNA, Inc.
- Agent Monte R. Browder
- International Application: PCT/US2011/022304 WO 20110125
- International Announcement: WO2011/091390 WO 20110728
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; A61K31/7088 ; C12N9/22
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of RNase H1, in particular, by targeting natural antisense polynucleotides of RNase H1. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of RNASE H1.
Public/Granted literature
- US20120295959A1 TREATMENT OF RNASE H1 RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO RNASE H1 Public/Granted day:2012-11-22
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