Invention Grant
US08946187B2 Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
有权
与microRNA-21，错配修复和结肠直肠癌相关的材料和方法
- Patent Title: Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
- Patent Title (中): 与microRNA-21，错配修复和结肠直肠癌相关的材料和方法
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Application No.: US13884668Application Date: 2011-11-11
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Publication No.: US08946187B2Publication Date: 2015-02-03
- Inventor: Carlo M. Croce , Nicola Valeri
- Applicant: Carlo M. Croce , Nicola Valeri
- Applicant Address: US OH Columbus
- Assignee: The Ohio State University
- Current Assignee: The Ohio State University
- Current Assignee Address: US OH Columbus
- Agency: MacMillan, Sobanski & Todd, LLC
- International Application: PCT/US2011/060349 WO 20111111
- International Announcement: WO2012/065049 WO 20120518
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/113 ; A61K31/513 ; A61K31/713 ; G01N33/574
Abstract:
The present invention discloses the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed in the present invention.
Public/Granted literature
- US20140045918A1 Materials and Methods Related to MicroRNA-21, Mismatch Repair, and Colorectal Cancer Public/Granted day:2014-02-13
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