Invention Grant
- Patent Title: Benzodioxane inhibitors of leukotriene production
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Application No.: US13785034Application Date: 2013-03-05
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Publication No.: US08946203B2Publication Date: 2015-02-03
- Inventor: Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
- Applicant: Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; David L. Kershner
- Main IPC: C07D519/00
- IPC: C07D519/00 ; C07D491/04 ; C07D487/08 ; A61K31/357 ; C07D491/052 ; C07D405/10 ; C07D295/096 ; C07D295/155 ; C07D513/04 ; C07D405/14 ; C07D319/20 ; C07D405/12 ; C07D487/10 ; C07D413/10 ; C07D417/10 ; C07D417/14 ; C07D471/10 ; C07D487/04
Abstract:
The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
Public/Granted literature
- US20130244996A1 BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION Public/Granted day:2013-09-19
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