Invention Grant
- Patent Title: Fused aminodihydrothiazine derivatives
- Patent Title (中): 融合氨基二氢噻嗪衍生物
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Application No.: US13333238Application Date: 2011-12-21
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Publication No.: US08946210B2Publication Date: 2015-02-03
- Inventor: Yuichi Suzuki , Takafumi Motoki , Toshihiko Kaneko , Mamoru Takaishi , Tasuku Ishida , Yoichi Kita , Kunitoshi Takeda , Noboru Yamamoto , Afzal Khan , Paschalis Dimopoulos
- Applicant: Yuichi Suzuki , Takafumi Motoki , Toshihiko Kaneko , Mamoru Takaishi , Tasuku Ishida , Yoichi Kita , Kunitoshi Takeda , Noboru Yamamoto , Afzal Khan , Paschalis Dimopoulos
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2008-008680 20080118; JP2008-197204 20080731
- Main IPC: C07D239/14
- IPC: C07D239/14 ; A61K31/5415

Abstract:
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
Public/Granted literature
- US20120094984A1 FUSED AMINODIHYDROTHIAZINE DERIVATIVES Public/Granted day:2012-04-19
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