Invention Grant
- Patent Title: Fused aminodihydrothiazine derivatives
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Application No.: US13804691Application Date: 2013-03-14
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Publication No.: US08946211B2Publication Date: 2015-02-03
- Inventor: Yuichi Suzuki , Takafumi Motoki , Toshihiko Kaneko , Mamoru Takaishi , Tasuku Ishida , Yoichi Kita , Kunitoshi Takeda , Noboru Yamamoto , Afzal Khan , Paschalis Dimopoulos
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP2008-008680 20080118; JP2008-197204 20080731
- Main IPC: C07D513/02
- IPC: C07D513/02 ; A61K31/542

Abstract:
A compound represented by the general formula: or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
Public/Granted literature
- US20130203741A1 FUSED AMINODIHYDROTHIAZINE DERIVATIVES Public/Granted day:2013-08-08
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