Invention Grant
US08946212B2 Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals
有权
具有恶二唑酮头孢的N-环杂环磺酰胺,其制备方法及其作为药物的用途
- Patent Title: Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals
- Patent Title (中): 具有恶二唑酮头孢的N-环杂环磺酰胺,其制备方法及其作为药物的用途
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Application No.: US12996692Application Date: 2009-05-22
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Publication No.: US08946212B2Publication Date: 2015-02-03
- Inventor: Stefanie Keil , Matthias Urmann , Wolfgang Wendler , Maike Glien , Hans Matter , Eugen Falk
- Applicant: Stefanie Keil , Matthias Urmann , Maike Glien , Hans Matter , Eugen Falk , Ulrike Wendler
- Applicant Address: FR Paris
- Assignee: Sanofi-Aventis
- Current Assignee: Sanofi-Aventis
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP08290572 20080609
- International Application: PCT/EP2009/003648 WO 20090522
- International Announcement: WO2009/149820 WO 20091217
- Main IPC: A61K31/538
- IPC: A61K31/538 ; C07D413/10 ; C07D413/12 ; C07D413/14 ; C07D417/10 ; C07D471/04 ; C07D498/04

Abstract:
Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals The invention relates to annelated N-heterocyclic sulfonamides with oxadiazolone headgroup and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARalpha agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
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