Invention Grant
- Patent Title: Indazole derivatives useful as ERK inhibitors
- Patent Title (中): 用作ERK抑制剂的吲唑衍生物
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Application No.: US13819366Application Date: 2011-08-29
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Publication No.: US08946216B2Publication Date: 2015-02-03
- Inventor: Yonqi Deng , Gerald W. Shipps, Jr. , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Kiran Muppalla
- Applicant: Yonqi Deng , Gerald W. Shipps, Jr. , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Kiran Muppalla
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Richard S. Parr; Laura M. Ginkel
- International Application: PCT/US2011/049483 WO 20110829
- International Announcement: WO2012/030685 WO 20120308
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D413/14 ; C07D417/14 ; A61K31/541 ; A61K31/5377 ; A61K31/496 ; A61K31/4545 ; A61K45/06 ; C07D417/12 ; C07D491/113
Abstract:
The present invention provides a compound of the Formula I: Formula I or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, R4, X, m and n are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
Public/Granted literature
- US20130158020A1 INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS Public/Granted day:2013-06-20
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