Invention Grant
US08946225B2 Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors
有权
2H哒嗪-3-酮的衍生物，其制备及其作为SCD-1抑制剂的用途
- Patent Title: Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors
- Patent Title (中): 2H哒嗪-3-酮的衍生物，其制备及其作为SCD-1抑制剂的用途
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Application No.: US13388884Application Date: 2010-08-05
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Publication No.: US08946225B2Publication Date: 2015-02-03
- Inventor: Elisabeth Dupont-Passelaigue , Samuel Mialhe , Jean-Pierre Rieu , Didier Junquero , Karine Valeille
- Applicant: Elisabeth Dupont-Passelaigue , Samuel Mialhe , Jean-Pierre Rieu , Didier Junquero , Karine Valeille
- Applicant Address: FR Boulogne-Billancourt
- Assignee: Pierre Fabre Medicament
- Current Assignee: Pierre Fabre Medicament
- Current Assignee Address: FR Boulogne-Billancourt
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FR0955504 20090805
- International Application: PCT/EP2010/061426 WO 20100805
- International Announcement: WO2011/015629 WO 20110210
- Main IPC: A61K31/50
- IPC: A61K31/50 ; A61K31/501 ; C07D237/02
Abstract:
The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: —R1 represents one or more groups such as: trifluoromethyl, halogen such as F, Cl, —when n=m=1, W represents CH then Y represents oxygen, —U represents: •either —(C═O)CH2NH— and is branched at position 4 of pyridazinone, then R2 represents H, •or —(C═O)NH— and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, —R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders.
Public/Granted literature
- US20120178678A1 DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS Public/Granted day:2012-07-12
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