Invention Grant
US08946239B2 Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
有权
具有抗有丝分裂和/或抗肿瘤活性的取代的吡咯并 - 呋喃和环戊基嘧啶及其使用方法
- Patent Title: Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
- Patent Title (中): 具有抗有丝分裂和/或抗肿瘤活性的取代的吡咯并 - 呋喃和环戊基嘧啶及其使用方法
-
Application No.: US12170571Application Date: 2008-07-10
-
Publication No.: US08946239B2Publication Date: 2015-02-03
- Inventor: Aleem Gangjee
- Applicant: Aleem Gangjee
- Applicant Address: US PA Pittsburgh
- Assignee: Duquesne University of the Holy Spirit
- Current Assignee: Duquesne University of the Holy Spirit
- Current Assignee Address: US PA Pittsburgh
- Agency: Buchanan Ingersoll & Rooney PC
- Agent Craig G. Cochenour
- Main IPC: C07D491/04
- IPC: C07D491/04 ; A61K31/519 ; C07D491/048 ; C07D487/04 ; C07D239/70
Abstract:
The present invention provides substituted pyrrolo-, furano-, and cyclopentylpyrimidine bicyclic compounds of formula III, and 5,6-saturated and unsaturated and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
Public/Granted literature
- US20100010016A1 BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF Public/Granted day:2010-01-14
Information query
