Invention Grant
US08946259B2 Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors
有权
苯并唑衍生物，组合物和用作β-分泌酶抑制剂的方法
- Patent Title: Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors
- Patent Title (中): 苯并唑衍生物，组合物和用作β-分泌酶抑制剂的方法
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Application No.: US14064737Application Date: 2013-10-28
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Publication No.: US08946259B2Publication Date: 2015-02-03
- Inventor: Adnan M. M. Mjalli , David Robert Jones , Devi Reddy Gohimukkula , Guoxiang Huang , Jeff Jiqun Zhu , Mohan Rao , Robert Carl Andrews , Tan Ren
- Applicant: High Point Pharmaceuticals, LLC
- Applicant Address: US NC High Point
- Assignee: High Point Pharmaceuticals, LLC
- Current Assignee: High Point Pharmaceuticals, LLC
- Current Assignee Address: US NC High Point
- Agent Samuel B. Rollins
- Main IPC: C07D401/12
- IPC: C07D401/12 ; A61K31/4725 ; C07D401/14 ; C07D235/30 ; C07D401/04 ; C07D403/12 ; C07D403/14 ; C07D405/14 ; C07D407/14 ; C07D409/14 ; C07D417/04 ; C07D417/14 ; C07D471/04 ; C07D473/00 ; C07D491/04 ; C07D495/04 ; C07D513/04
Abstract:
The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which BACE is involved.
Public/Granted literature
- US20140066477A1 Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors Public/Granted day:2014-03-06
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