Invention Grant
US08946266B2 Substituted triazole and imidazole derivatives as gamma secretase modulators
有权
取代的三唑和咪唑衍生物作为γ分泌酶调节剂
- Patent Title: Substituted triazole and imidazole derivatives as gamma secretase modulators
- Patent Title (中): 取代的三唑和咪唑衍生物作为γ分泌酶调节剂
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Application No.: US13382659Application Date: 2010-07-13
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Publication No.: US08946266B2Publication Date: 2015-02-03
- Inventor: Tongfei Wu , Henricus Jacobus Maria Gijsen , Frederik Jan Rita Rombouts , François Paul Bischoff , Didier Jean-Claude Berthelot , Daniel Oehlrich , Michel Anna Jozef De Cleyn , Serge Maria Aloysius Pieters , Garrett Berlond Minne , Adriana Ingrid Velter′ , Sven Franciscus Anna Van Brandt , Michel Surkyn
- Applicant: Tongfei Wu , Henricus Jacobus Maria Gijsen , Frederik Jan Rita Rombouts , François Paul Bischoff , Didier Jean-Claude Berthelot , Daniel Oehlrich , Michel Anna Jozef De Cleyn , Serge Maria Aloysius Pieters , Garrett Berlond Minne , Adriana Ingrid Velter′ , Sven Franciscus Anna Van Brandt , Michel Surkyn
- Applicant Address: US NJ Titusville GB Brentford, Middlesex
- Assignee: Janssen Pharmaceuticals, Inc.,Cellzome Limited
- Current Assignee: Janssen Pharmaceuticals, Inc.,Cellzome Limited
- Current Assignee Address: US NJ Titusville GB Brentford, Middlesex
- Agency: Baker & Hostetler LLP
- Priority: EP09165585 20090715; EP10164625 20100601
- International Application: PCT/EP2010/060083 WO 20100713
- International Announcement: WO2011/006903 WO 20110120
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; C07D401/14 ; C07D233/60 ; C07D403/10 ; C07D405/14 ; C07D471/04 ; C07D487/04 ; C07D498/04
Abstract:
The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Public/Granted literature
- US20120135981A1 NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS Public/Granted day:2012-05-31
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