Invention Grant
US08946291B2 Compositions and methods for treating pigmentary conditions and melanoma
有权
用于治疗色素病症和黑色素瘤的组合物和方法
- Patent Title: Compositions and methods for treating pigmentary conditions and melanoma
- Patent Title (中): 用于治疗色素病症和黑色素瘤的组合物和方法
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Application No.: US13059219Application Date: 2008-08-15
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Publication No.: US08946291B2Publication Date: 2015-02-03
- Inventor: Vincent J. Hearing , Thierry Passeron
- Applicant: Vincent J. Hearing , Thierry Passeron
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US DC Washington
- Agency: Swanson & Bratschun, L.L.C.
- International Application: PCT/US2008/009762 WO 20080815
- International Announcement: WO2010/019120 WO 20100218
- Main IPC: A61K31/203
- IPC: A61K31/203 ; A61K31/5575 ; A61P35/00 ; A61K38/17
Abstract:
A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating a hyperpigmentary condition in a subject comprising administering an amount of inhibitor of SOX9 activity sufficient to treat the condition is disclosed. A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising increasing the amounts of retinoic acid and SOX9 in the subject by amounts sufficient to treat melanoma. A method of treating melanoma in a subject comprising administering an amount of prostaglandin D2 and retinoic acid sufficient to treat cancer is disclosed. A method of sensitizing a melanoma cell to RA comprising administering an amount of SOX9 sufficient to decrease PRAME expression is disclosed.
Public/Granted literature
- US20110269691A1 Compositions and Methods for Treating Pigmentary Conditions and Melanoma Public/Granted day:2011-11-03
Information query
IPC分类:
