Invention Grant
US08946422B2 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
有权
8-甲氧基-9H-异噻唑并[5,4-B]喹啉-3,4-二酮和相关化合物作为抗感染剂
- Patent Title: 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
- Patent Title (中): 8-甲氧基-9H-异噻唑并[5,4-B]喹啉-3,4-二酮和相关化合物作为抗感染剂
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Application No.: US13279852Application Date: 2011-10-24
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Publication No.: US08946422B2Publication Date: 2015-02-03
- Inventor: Barton James Bradbury , Jason Allan Wiles , Qiuping Wang , Akhiro Hashimoto , Edlaine Lucien , Godwin Clarence Gilroy Pais , Milind Deshpande , Micheal John Pucci , Ha Young Kim
- Applicant: Barton James Bradbury , Jason Allan Wiles , Qiuping Wang , Akhiro Hashimoto , Edlaine Lucien , Godwin Clarence Gilroy Pais , Milind Deshpande , Micheal John Pucci , Ha Young Kim
- Applicant Address: US CT New Haven
- Assignee: Achillion Pharmaceuticals, Inc.
- Current Assignee: Achillion Pharmaceuticals, Inc.
- Current Assignee Address: US CT New Haven
- Agency: Cantor Colburn LLP
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61K31/496 ; A61P33/02 ; C07D513/14 ; C07D495/04 ; C07D498/04 ; C07D513/04
![8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents](/abs-image/US/2015/02/03/US08946422B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
Public/Granted literature
- US20120040959A1 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS Public/Granted day:2012-02-16
Information query
IPC分类: