Invention Grant
US08946431B2 2-(substituted ethynyl)quinoline derivatives as mGLUr5 antagonists
有权
2-（取代的乙炔基）喹啉衍生物作为mGLUr5拮抗剂
- Patent Title: 2-(substituted ethynyl)quinoline derivatives as mGLUr5 antagonists
- Patent Title (中): 2-（取代的乙炔基）喹啉衍生物作为mGLUr5拮抗剂
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Application No.: US13943019Application Date: 2013-07-16
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Publication No.: US08946431B2Publication Date: 2015-02-03
- Inventor: Sun Joon Min , Yong Seo Cho , Ae Nim Pae , Eun Jeong Lim , Ji Yeong Kim , Myung Hee Son , Jae Kyun Lee
- Applicant: Korea Institute of Science and Technology
- Applicant Address: KR Seoul
- Assignee: Korea Institute of Science and Technology
- Current Assignee: Korea Institute of Science and Technology
- Current Assignee Address: KR Seoul
- Agency: Staas & Halsey LLP
- Priority: KR10-2013-0007540 20130123
- Main IPC: C07D215/06
- IPC: C07D215/06 ; A61K31/04 ; C07D215/20 ; C07D401/06
Abstract:
Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).
Public/Granted literature
- US20140206876A1 2-(Substituted ethynyl)quinoline Derivatives as mGLUr5 Antagonists Public/Granted day:2014-07-24
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