Invention Grant
US08946446B2 Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-γ (ROR-γ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
有权
用于调节孤儿核受体RAR相关孤儿受体γ（ROR-γ，NR1F3）活性和治疗慢性炎症和自身免疫疾病的吡咯磺酰胺化合物
- Patent Title: Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-γ (ROR-γ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
- Patent Title (中): 用于调节孤儿核受体RAR相关孤儿受体γ（ROR-γ，NR1F3）活性和治疗慢性炎症和自身免疫疾病的吡咯磺酰胺化合物
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Application No.: US14110702Application Date: 2012-04-13
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Publication No.: US08946446B2Publication Date: 2015-02-03
- Inventor: Christoph Steeneck , Olaf Kinzel , Christian Gege , Gerald Kleymann , Thomas Hoffmann
- Applicant: Christoph Steeneck , Olaf Kinzel , Christian Gege , Gerald Kleymann , Thomas Hoffmann
- Applicant Address: DE Ludwigshafen
- Assignee: Phenex Pharmaceuticals AG
- Current Assignee: Phenex Pharmaceuticals AG
- Current Assignee Address: DE Ludwigshafen
- Agency: Seed IP Law Group PLLC
- Priority: EP11003169 20110414
- International Application: PCT/EP2012/001621 WO 20120413
- International Announcement: WO2012/139775 WO 20121018
- Main IPC: C07D209/02
- IPC: C07D209/02 ; C07D207/00 ; C07D215/00 ; C07D401/00 ; C07D413/00 ; A61K31/44 ; A61K31/535 ; A61K31/397 ; A61K31/445 ; A61K31/40 ; C07D209/30 ; C07D207/36 ; C07D401/04 ; C07D403/04 ; C07D403/10
Abstract:
The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
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