Invention Grant
US08946481B2 Process for preparing biaryl substituted 4-amino butyric acid or derivatives thereof and their use in the production of NEP inhibitors
有权
联芳基取代的4-氨基丁酸或其衍生物的制备方法及其在NEP抑制剂生产中的应用
- Patent Title: Process for preparing biaryl substituted 4-amino butyric acid or derivatives thereof and their use in the production of NEP inhibitors
- Patent Title (中): 联芳基取代的4-氨基丁酸或其衍生物的制备方法及其在NEP抑制剂生产中的应用
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Application No.: US13661991Application Date: 2012-10-26
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Publication No.: US08946481B2Publication Date: 2015-02-03
- Inventor: David Hook , Bernhard Wietfeld , Matthias Lotz
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Matthew Mulkeen
- Priority: EP06120576 20060913
- Main IPC: C07C211/00
- IPC: C07C211/00 ; C07C269/06
Abstract:
The invention relates to a process for producing a compound according to formula (i) or salt thereof, wherein R1 and R1′ are independently hydrogen or an amine protecting group and R2 is a carboxyl group or an ester group, comprising reacting a compound according to formula (ii) or salt thereof, wherein R1, R1′ and R2 are defined as above, with hydrogen in the presence of a transition metal catalyst and a chiral ligand, wherein the transition metal is selected from group 7, 8 or 9 of the periodic table. Furthermore, the invention relates to products obtainable by said process and to their use in the production of NEP inhibitors. Moreover, the invention relates to the use of transition metal catalyst in the preparation of NEP inhibitors or prodrugs thereof.
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