Systems and methods for developing and using adaptive threshold values for different input images for object detection are disclosed. In embodiments, detector response histogram-based systems and methods train models for predicting optimal threshold values for different images. In embodiments, when training the model, an optimal threshold value for an image is defined as the value that maximizes the reduction of false positive image patches while preserving as many true positive image patches as possible. Once trained, the model may be used to set different threshold values for different images by inputting a detector response histogram for the image patches of an image into the model to determine a threshold value for detection.