Dynamic relocation of virtual machines among hypervisors in a domain is provided. A domain management module is executed on a computer processor and is configured to receive a request to add a new hypervisor to a domain. Each hypervisor and each domain comprises an architecture description (ARD). A new canonical ARD is generated for all hypervisors in the domain. A virtual machine executing on a first system is relocated to any other hypervisor in the domain. Virtual machines may also be moved to out-of-domain hypervisors through the use of override masks. In addition, under certain conditions, new hypervisors additions, as well as hypervisor and system updates may be performed without disrupting the virtual machines that are controlled by the hypervisors.