A firearm with slide takedown mechanism and method for use is disclosed. In one embodiment, the firearm includes a frame, barrel, trigger and a reciprocating slide. A takedown lever is pivotably mounted to the firearm and engageable with the slide. In a first blocking position, the takedown lever engages and blocks the rearward path of the slide which is not movable beyond a first position. In a second unblocking position, the takedown lever is pivoted laterally outwards from the frame and disengages the slide. The rearward path of the slide is no longer blocked which may be moved to a second rearward removal position enabling a user to remove the slide and field strip the firearm. In one embodiment, the takedown lever is disposed underneath the frame. The firearm may be a semi-automatic pistol in some embodiments.