A housing structure includes a main cabinet and an engaging mechanism. The main cabinet has an opening formed on one side, and the main cabinet has a side panel and a latch. The opening can be covered up by the side panel, and the latch can be movably arranged on the side panel. The engaging mechanism includes a sliding member and an elastic member, and the sliding member can be slidably arranged on the main cabinet and is adjacent to the latch. A plurality of grooves is formed on the sliding member, and a plurality of hooks is formed correspondingly on the side panel. The sliding member can traverse between a default and a release position to assemble or dissemble the main cabinet.