Invention Grant
- Patent Title: Variant immunoglobulins with improved manufacturability
- Patent Title (中): 具有改进的可制造性的变体免疫球蛋白
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Application No.: US13390996Application Date: 2010-08-20
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Publication No.: US08951516B2Publication Date: 2015-02-10
- Inventor: Andreas Arnell , Jose Jimenez , Rebecca Michael , Yvette Stallwood , Jesus Zurdo
- Applicant: Andreas Arnell , Jose Jimenez , Rebecca Michael , Yvette Stallwood , Jesus Zurdo
- Applicant Address: GB Slough, Berkshire
- Assignee: Lonza Biologics PLC
- Current Assignee: Lonza Biologics PLC
- Current Assignee Address: GB Slough, Berkshire
- Agency: Fish & Richardson P.C.
- Priority: GB0914691.1 20090821
- International Application: PCT/GB2010/001579 WO 20100820
- International Announcement: WO2011/021009 WO 20110224
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/395
Abstract:
This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.
Public/Granted literature
- US20120148568A1 Variant Immunoglobulins with Improved Manufacturability Public/Granted day:2012-06-14
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