Invention Grant
- Patent Title: Modified Streptococcus pneumonia pneumolysin (PLY) polypeptides
- Patent Title (中): 改良型肺炎链球菌肺炎球菌（PLY）多肽
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Application No.: US14269501Application Date: 2014-05-05
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Publication No.: US08951531B2Publication Date: 2015-02-10
- Inventor: Eliud Oloo , Raymond Oomen , Martina Ochs-Onolemhemhen , Jeremy Yethon
- Applicant: The Kingdom of The Netherlands, Represented by The Minister of Health, Welfare and Sport
- Applicant Address: NL Bilthoven
- Assignee: The Kingdom of the Netherlands, Represented by the Minister of Health, Welfare and Sport, on Behalf of the Minister, The National Institute of Public Health and the Environment
- Current Assignee: The Kingdom of the Netherlands, Represented by the Minister of Health, Welfare and Sport, on Behalf of the Minister, The National Institute of Public Health and the Environment
- Current Assignee Address: NL Bilthoven
- Agent Patrick J. Halloran; Reza Yacoub
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/02 ; A61K39/09 ; A61K39/38 ; C07K14/315 ; C07K16/12
Abstract:
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise amino acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
Public/Granted literature
- US20140341942A1 Modified Streptococcus Pneumonia Pneumolysin (PLY) Polypeptides Public/Granted day:2014-11-20
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