Invention Grant
- Patent Title: Exopolysaccharide of Shigella sonnei bacteria, method for producing same, vaccine and phamaceutical composition containing same
- Patent Title (中): 志贺氏菌属细菌外多糖,其生产方法,含有该菌的疫苗和药物组合物
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Application No.: US13855522Application Date: 2013-04-02
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Publication No.: US08951538B2Publication Date: 2015-02-10
- Inventor: Petr Gennadievich Aparin , Vyacheslav Leonidovich Lvov , Stanislava Ivanovna Elkina , Marina Eduardovna Golovina , Vladimir Igorevich Shmigol
- Applicant: Petr Gennadievich Aparin , Vyacheslav Leonidovich Lvov , Stanislava Ivanovna Elkina , Marina Eduardovna Golovina , Vladimir Igorevich Shmigol
- Agent Nadya Reingand; Yan Hankin
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A61K45/00 ; A61K39/00 ; A61K39/112 ; A61K47/00

Abstract:
For the first time, an O-specific polysaccharide antigen that is a Shigella sonnei, phase I, exopolysaccharide has been produced and characterized, said exopolysaccharide being an authentic natural compound in the form of a bacterial capsular polysaccharide. The exopolysaccharide contains a non-toxic lipid component, namely non-hydroxylated fatty acids, and exhibits low pyrogenicity and high immunogenicity. Effective, highly specific and safe vaccines for the prophylaxis and/or treatment of Shigella sonnei shigellosis are developed on the basis of the above-mentioned exopolysaccharide, as well as pharmaceutical compositions with a broad spectrum of action, in particular, in modulating immune response.
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