Invention Grant
US08951538B2 Exopolysaccharide of Shigella sonnei bacteria, method for producing same, vaccine and phamaceutical composition containing same 有权
志贺氏菌属细菌外多糖,其生产方法,含有该菌的疫苗和药物组合物

Exopolysaccharide of Shigella sonnei bacteria, method for producing same, vaccine and phamaceutical composition containing same
Abstract:
For the first time, an O-specific polysaccharide antigen that is a Shigella sonnei, phase I, exopolysaccharide has been produced and characterized, said exopolysaccharide being an authentic natural compound in the form of a bacterial capsular polysaccharide. The exopolysaccharide contains a non-toxic lipid component, namely non-hydroxylated fatty acids, and exhibits low pyrogenicity and high immunogenicity. Effective, highly specific and safe vaccines for the prophylaxis and/or treatment of Shigella sonnei shigellosis are developed on the basis of the above-mentioned exopolysaccharide, as well as pharmaceutical compositions with a broad spectrum of action, in particular, in modulating immune response.
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