Invention Grant
US08951743B2 Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways
有权
检测脱落CD31，动脉粥样硬化血栓形成和自身免疫性疾病的诊断，以及分析信号通路的方法
- Patent Title: Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways
- Patent Title (中): 检测脱落CD31，动脉粥样硬化血栓形成和自身免疫性疾病的诊断，以及分析信号通路的方法
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Application No.: US13001815Application Date: 2009-06-30
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Publication No.: US08951743B2Publication Date: 2015-02-10
- Inventor: Giuseppina Caligiuri , Antonino Nicoletti
- Applicant: Giuseppina Caligiuri , Antonino Nicoletti
- Applicant Address: FR Paris
- Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris
- Agency: Whitham, Curtis, Christofferson & Cook, P.C.
- Priority: EP08305361 20080630; EP09305116 20090209
- International Application: PCT/EP2009/058220 WO 20090630
- International Announcement: WO2010/000756 WO 20100107
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/543 ; G01N33/68
Abstract:
The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex.
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