Invention Grant
- Patent Title: Malonate decarboxylases for industrial applications
- Patent Title (中): 用于工业应用的丙二酸脱羧酶
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Application No.: US12744937Application Date: 2008-11-28
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Publication No.: US08951750B2Publication Date: 2015-02-10
- Inventor: Bernhard Hauer , Nina Schneider , Krzysztof Okrasa , Jason Micklefield , David Leys , Colin Levy
- Applicant: Bernhard Hauer , Nina Schneider , Krzysztof Okrasa , Jason Micklefield , David Leys , Colin Levy
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Agency: Drinker Biddle & Reath LLP
- Priority: EP07023075 20071128; EP08156393 20080516
- International Application: PCT/EP2008/010131 WO 20081128
- International Announcement: WO2009/068308 WO 20090604
- Main IPC: C12Q1/64
- IPC: C12Q1/64 ; G01N33/53 ; C07B37/06 ; C12N9/88 ; C07K14/235 ; C12N9/90 ; C12P7/40 ; C12P7/42 ; C12Q1/00
Abstract:
The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.
Public/Granted literature
- US20100311037A1 MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS Public/Granted day:2010-12-09
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