Invention Grant
US08951762B2 Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
有权
在脂肪酸合成中使用酰基酰基载体蛋白硫酯酶及其突变体和嵌合体的材料和方法
- Patent Title: Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis
- Patent Title (中): 在脂肪酸合成中使用酰基酰基载体蛋白硫酯酶及其突变体和嵌合体的材料和方法
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Application No.: US13558323Application Date: 2012-07-25
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Publication No.: US08951762B2Publication Date: 2015-02-10
- Inventor: Basil J. Nikolau , Marna Yandeau-Nelson , Fuyuan Jing
- Applicant: Basil J. Nikolau , Marna Yandeau-Nelson , Fuyuan Jing
- Applicant Address: US IA Ames
- Assignee: Iowa State University Research Foundation, Inc.
- Current Assignee: Iowa State University Research Foundation, Inc.
- Current Assignee Address: US IA Ames
- Agency: Larcher & Chao Law Group
- Agent Carol Larcher
- Main IPC: C12P7/64
- IPC: C12P7/64 ; C12N9/16 ; C12N1/20 ; C12N1/00 ; C12N1/12 ; C07H21/04
Abstract:
A method of increasing production of fatty acids comprising introducing into a host cell or organism and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE) from Bryantella formatexigens or a mutant thereof; a method of making a mutant B. formatexigens acyl-ACP TE; a method of making a chimeric Cuphea viscosissima acyl-ACP TE; a nucleic acid encoding a mutant acyl-ACP TE or a chimeric C. viscosissima acyl-ACP TE; a host cell or organism comprising the nucleic acid; a mutant acyl-ACP TE or chimeric C. viscosissima acyl-ACP TE; a method of altering the specificity of a plant acyl-ACP TE; and a method of altering the level of activity of a plant acyl-ACP TE.
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