Invention Grant
US08951789B2 Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same
有权
包含人细胞色素P450基因（簇）和非人哺乳动物的哺乳动物人造染色体载体保持相同
- Patent Title: Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same
- Patent Title (中): 包含人细胞色素P450基因（簇）和非人哺乳动物的哺乳动物人造染色体载体保持相同
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Application No.: US12743065Application Date: 2008-10-14
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Publication No.: US08951789B2Publication Date: 2015-02-10
- Inventor: Mitsuo Oshimura , Yasuhiro Kazuki , Takashi Matsuoka , Kazuma Tomizuka , Takeshi Oshima
- Applicant: Mitsuo Oshimura , Yasuhiro Kazuki , Takashi Matsuoka , Kazuma Tomizuka , Takeshi Oshima
- Applicant Address: JP Tottori-shi JP Yonago-shi
- Assignee: National University Corporation Tottori University,Chromocenter Inc.
- Current Assignee: National University Corporation Tottori University,Chromocenter Inc.
- Current Assignee Address: JP Tottori-shi JP Yonago-shi
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007-295993 20071114
- International Application: PCT/JP2008/068928 WO 20081014
- International Announcement: WO2009/063722 WO 20090522
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C12N5/06 ; C12N15/85 ; A01K67/027 ; C12N9/02 ; G01N33/50 ; A01K67/00
Abstract:
This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb±500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector.
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