Invention Grant
- Patent Title: Revascularization cells derived from mononuclear cells, and method of inducing differentiation thereof
- Patent Title (中): 来自单核细胞的血运重建细胞及其诱导分化的方法
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Application No.: US13138835Application Date: 2010-03-29
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Publication No.: US08951795B2Publication Date: 2015-02-10
- Inventor: Yusuke Mizukami , Junpei Sasajima , Yoshiaki Sugiyama , Kazuya Sato , Yutaka Kohgo
- Applicant: Yusuke Mizukami , Junpei Sasajima , Yoshiaki Sugiyama , Kazuya Sato , Yutaka Kohgo
- Applicant Address: JP Hokkaido
- Assignee: National University Corporation Asahikawa Medical University
- Current Assignee: National University Corporation Asahikawa Medical University
- Current Assignee Address: JP Hokkaido
- Agency: Pearne & Gordon LLP
- Priority: JP2009-093459 20090407
- International Application: PCT/JP2010/002254 WO 20100329
- International Announcement: WO2010/116665 WO 20101014
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/078 ; A61K35/12
Abstract:
The present invention relates to a method of safely and simply inducing differentiation of mononuclear cells into cells that promote neovascular stabilization and maturation, and lead to recovering from ischemia or tissue repair. The cells according to the present invention are obtained by inducing differentiation of a mononuclear cell by culturing the mononuclear cell in a medium (particularly a serum-free medium) containing one or more selected from vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), thrombopoietin (TPO), granulocyte-colony stimulating factor (G-CSF) and FMS-like tyrosine kinase 3 ligand (FLT3L), and collecting a cell population expressing CD11b.
Public/Granted literature
- US20120100610A1 REVASCULARIZATION CELLS DERIVED FROM MONONUCLEAR CELLS, AND METHOD OF INDUCING DIFFERENTIATION THEREOF Public/Granted day:2012-04-26
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