Invention Grant
US08951937B2 Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases
有权
鉴定和使用细菌[2Fe-2S]二羟基酸脱水酶
![Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases](/docs/US/2015-02-10/US08951937B2/abs.jpg.600x600.jpg)
- Patent Title: Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases
- Patent Title (中): 鉴定和使用细菌[2Fe-2S]二羟基酸脱水酶
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Application No.: US13838508Application Date: 2013-03-15
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Publication No.: US08951937B2Publication Date: 2015-02-10
- Inventor: Dennis Flint , Steven Cary Rothman , Wonchul Suh , Jean-Francois Tomb , Rick W. Ye
- Applicant: Butamax(TM) Advanced Biofuels LLC
- Applicant Address: US DE Wilmington
- Assignee: Butamax Advanced Biofuels LLC
- Current Assignee: Butamax Advanced Biofuels LLC
- Current Assignee Address: US DE Wilmington
- Main IPC: C40B30/00
- IPC: C40B30/00 ; C12P21/00 ; G06F19/22 ; C12P7/16 ; C12P7/40 ; C12P13/06 ; C12P13/08 ; C12N1/21 ; C12N1/19 ; C12N9/88 ; C12N15/00 ; C12N5/10
![Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases](/abs-image/US/2015/02/10/US08951937B2/abs.jpg.150x150.jpg)
Abstract:
A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing DHAD activity for conversion of 2,3-dihydroxyisovalerate to α-ketoisovalerate or 2,3-dihydroxymethylvalerate to α-ketomethylvalerate. Isobutanol and other compounds may be synthesized in pathways that include bacterial [2Fe-2S] DHAD activity.
Public/Granted literature
- US20140030776A1 IDENTIFICATION AND USE OF BACTERIAL [2Fe-2S] DIHYDROXY-ACID DEHYDRATASES Public/Granted day:2014-01-30
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