Invention Grant
- Patent Title: Glucagon-like peptide-1 analogues and uses thereof
- Patent Title (中): 胰高血糖素样肽-1类似物及其用途
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Application No.: US13643840Application Date: 2011-04-29
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Publication No.: US08951959B2Publication Date: 2015-02-10
- Inventor: Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
- Applicant: Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
- Applicant Address: CN Hangzhou, Zhejiang
- Assignee: Betta Pharmaceuticals Co., Ltd.
- Current Assignee: Betta Pharmaceuticals Co., Ltd.
- Current Assignee Address: CN Hangzhou, Zhejiang
- Agency: Greenberg Traurig, LLP
- Agent Weisun Rao
- Priority: CN201010156732 20100427; CN201110078365 20110330
- International Application: PCT/CN2011/000764 WO 20110429
- International Announcement: WO2011/134284 WO 20111103
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P9/10 ; C07K14/47 ; A61P3/04 ; A61K38/22 ; A61P3/08 ; A61P3/10 ; A61K38/26 ; A61P7/12 ; C07K14/605 ; A61K38/28 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00
Abstract:
Provided is a glucagon-like peptide-1 (GLP-1) analog shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analog has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analog is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analog in conquering blood sugar.
Public/Granted literature
- US20130053304A1 GLUCAGON-LIKE PEPTIDE-1 ANALOGUES AND USES THEREOF Public/Granted day:2013-02-28
Information query
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