Invention Grant
US08951966B2 Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases
有权
包含FGF19多肽的变体和融合物的组合物及其用于治疗代谢紊乱和疾病的用途及其方法
- Patent Title: Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases
- Patent Title (中): 包含FGF19多肽的变体和融合物的组合物及其用于治疗代谢紊乱和疾病的用途及其方法
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Application No.: US13538705Application Date: 2012-06-29
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Publication No.: US08951966B2Publication Date: 2015-02-10
- Inventor: Lei Ling , Darrin A. Lindhout
- Applicant: Lei Ling , Darrin A. Lindhout
- Applicant Address: US CA South San Francisco
- Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; C12N1/21 ; C12N5/10 ; C12N15/63 ; G01N33/50 ; A61K38/00
Abstract:
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
Public/Granted literature
- US20130023474A1 COMPOSITIONS, USES AND METHODS FOR TREATMENT OF METABOLIC DISORDERS AND DISEASES Public/Granted day:2013-01-24
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