Invention Grant
US08951981B2 Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
有权
通过抑制PON1的天然反义转录物治疗对氧磷酶1（PON1）相关疾病
- Patent Title: Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1
- Patent Title (中): 通过抑制PON1的天然反义转录物治疗对氧磷酶1（PON1）相关疾病
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Application No.: US13377884Application Date: 2010-06-16
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Publication No.: US08951981B2Publication Date: 2015-02-10
- Inventor: Joseph Collard , Olga Khorkova Sherman
- Applicant: Joseph Collard , Olga Khorkova Sherman
- Applicant Address: US FL Miami
- Assignee: CuRNA, Inc.
- Current Assignee: CuRNA, Inc.
- Current Assignee Address: US FL Miami
- Agency: CuRNA, Inc.
- Agent Monte R. Browder
- International Application: PCT/US2010/038785 WO 20100616
- International Announcement: WO2010/148065 WO 20101223
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1(PON1), in particular, by targeting natural antisense polynucleotides of Paraoxonase 1(PON1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PON1.
Public/Granted literature
- US20120095081A1 TREATMENT OF PARAOXONASE 1 (PON1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PON1 Public/Granted day:2012-04-19
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