Invention Grant
- Patent Title: Morphinan derivative
- Patent Title (中): 吗啡衍生物
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Application No.: US14343218Application Date: 2012-09-07
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Publication No.: US08952030B2Publication Date: 2015-02-10
- Inventor: Hiroshi Nagase , Hideaki Fujii , Eriko Nakata , Yoshikazu Watanabe , Toshihiro Takahashi
- Applicant: Hiroshi Nagase , Hideaki Fujii , Eriko Nakata , Yoshikazu Watanabe , Toshihiro Takahashi
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: The Kitasato Institute,Nippon Chemiphar Co., Ltd.
- Current Assignee: The Kitasato Institute,Nippon Chemiphar Co., Ltd.
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2011-196641 20110909; JP2012-168401 20120730
- International Application: PCT/JP2012/072868 WO 20120907
- International Announcement: WO2013/035833 WO 20130314
- Main IPC: A61K31/485
- IPC: A61K31/485 ; C07D491/18 ; C07D487/08 ; C07F7/18

Abstract:
A morphinan derivative represented by the following general formula (I): (in the formula, R1 represents hydrogen, C1-6 alkyl, cycloalkylalkyl (the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms), aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R2 represents hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C6-10 aryl, aralkyl (the aryl moiety has 6 to 10 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms) and the like, R3, R4 and R5 represent hydrogen, hydroxy, carbamoyl, C1-6 alkoxy, C6-10 aryloxy and the like, R6a, R6b, R7, R8, R9, and R10 represent hydrogen and the like, X represents O or CH2, and Y represents C═O, SO2, an atomic bond and the like), or an acid addition salt thereof is used as an analgesic.
Public/Granted literature
- US20140343015A1 MORPHINAN DERIVATIVE Public/Granted day:2014-11-20
Information query
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