Invention Grant
US08952061B2 Methods and compounds regulating the erythroid response to iron deficiency
有权
调节红细胞对铁缺乏反应的方法和化合物
- Patent Title: Methods and compounds regulating the erythroid response to iron deficiency
- Patent Title (中): 调节红细胞对铁缺乏反应的方法和化合物
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Application No.: US13680325Application Date: 2012-11-19
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Publication No.: US08952061B2Publication Date: 2015-02-10
- Inventor: Adam N. Goldfarb , Loretta L. Delehanty
- Applicant: Adam N. Goldfarb , Loretta L. Delehanty
- Applicant Address: US VA Charlottesville
- Assignee: University of Virginia Patent Foundation
- Current Assignee: University of Virginia Patent Foundation
- Current Assignee Address: US VA Charlottesville
- Agent Rodney L. Sparks
- Main IPC: A61K31/19
- IPC: A61K31/19 ; A61K38/18 ; A61K31/194 ; G06F17/30 ; H04L29/06 ; H04W12/08 ; C07C69/704 ; C12Q1/25 ; H04W80/08
Abstract:
The present invention discloses the signaling pathway involved erythroid repression by iron deficiency. Further disclosed is anon-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.
Public/Granted literature
- US20130072428A1 Methods and Compounds Regulating the Erythroid Response to Iron Deficiency Public/Granted day:2013-03-21
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