Invention Grant
- Patent Title: Antibodies to human programmed death receptor PD-1
- Patent Title (中): 人类程序性死亡受体PD-1的抗体
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Application No.: US13719756Application Date: 2012-12-19
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Publication No.: US08952136B2Publication Date: 2015-02-10
- Inventor: Gregory John Carven , Hans Van Eenenneem , Gradus Johannes Dulos
- Applicant: Merck Sharp & Dohme B.V.
- Applicant Address: NL Oss
- Assignee: Merck Sharp & Dohme B.V.
- Current Assignee: Merck Sharp & Dohme B.V.
- Current Assignee Address: NL Oss
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.
Public/Granted literature
- US20130109843A1 ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 Public/Granted day:2013-05-02
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