Invention Grant
- Patent Title: Process for the preparation of lapatinib and its ditosylate salt
- Patent Title (中): 拉帕替尼及其二甲磺酸盐的制备方法
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Application No.: US13997424Application Date: 2011-12-23
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Publication No.: US08952154B2Publication Date: 2015-02-10
- Inventor: Mohammed Abdul Raheem , Gamini Weeratunga , Carlos Zetina-Rocha , Eduardo Gustavo Cammisa
- Applicant: Mohammed Abdul Raheem , Gamini Weeratunga , Carlos Zetina-Rocha , Eduardo Gustavo Cammisa
- Applicant Address: CA Brantford
- Assignee: Apotex Pharmachem Inc.
- Current Assignee: Apotex Pharmachem Inc.
- Current Assignee Address: CA Brantford
- International Application: PCT/CA2011/001420 WO 20111223
- International Announcement: WO2012/083440 WO 20120628
- Main IPC: C07D239/72
- IPC: C07D239/72 ; C07D405/04 ; A61K31/517
Abstract:
There is provided processes for preparing Lapatinib and pharmaceutically acceptable salts thereof by the reductive amination of the aldehyde of Formula II by treatment with 2-methanesulphonylethylamine followed by catalytic hydrogenation in the presence of a suitable hydrogenation catalyst.
Public/Granted literature
- US20140018535A1 PROCESS FOR THE PREPARATION OF LAPATINIB AND ITS DITOSYLATE SALT Public/Granted day:2014-01-16
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