Invention Grant
US08952160B2 Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
有权
异噻唑 - 吡啶衍生物作为HIF（缺氧诱导因子）活性的调节剂
- Patent Title: Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
- Patent Title (中): 异噻唑 - 吡啶衍生物作为HIF（缺氧诱导因子）活性的调节剂
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Application No.: US12811821Application Date: 2009-01-12
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Publication No.: US08952160B2Publication Date: 2015-02-10
- Inventor: Xiaoti Zhou , Michael P. Arend , Min Wu , Lee A. Flippin
- Applicant: Xiaoti Zhou , Michael P. Arend , Min Wu , Lee A. Flippin
- Applicant Address: US CA San Francisco
- Assignee: Fibrogen, Inc.
- Current Assignee: Fibrogen, Inc.
- Current Assignee Address: US CA San Francisco
- Agency: Sheppard Mullin Richter & Hampton LLP
- International Application: PCT/US2009/030775 WO 20090112
- International Announcement: WO2009/089547 WO 20090716
- Main IPC: C07D513/04
- IPC: C07D513/04 ; A61K31/4439
Abstract:
The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II).
Public/Granted literature
- US20100330199A1 ISOTHIAZOLE-PYRIDINE DERIVATES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY Public/Granted day:2010-12-30
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