An active pixel CMOS image sensor implements full frame digital correlated double sampling (CDS) with global shutter where all the pixels in the image sensor are reset at substantially the same time and all the pixels in the image sensor integrate incident light at substantially the same time and for substantially the same time duration and correlated double sampling cancellation is performed in the digital domain. In one embodiment, the image sensing device includes an array of light sensing elements, a timing and control circuit and analog-to-digital converters. The timing and control circuit is operative to reset the light sensing elements in the array and to control the array of light sensing elements to integrate incident light. The pixel reset values are cancelled from the corresponding light dependent pixel values for each of the light sensing elements to generate correlated double sampling (CDS) corrected digital output pixel values.