Methods and apparatus permitting the coexistence of multiple communication links to distinct wireless systems in a client device are disclosed. A wireless device can interface with both a primary communications system and at least one distinct communications system by managing the coexistence of active communications with the multiple communication systems. The wireless device can initially configure communications with the primary communications system for dynamically reconfigurable time multiplexed operation having scheduled periods of inactivity. The wireless device can determine timing and scheduling of communications with the distinct communications systems and can schedule the communications with the distinct communications systems during periods of inactivity in the primary communications system. The periods of inactivity may be limited to the scheduled periods of inactivity or can include unscheduled periods of inactivity occurring during active periods of the time multiplexed operation. The device may also use data priorities of communications to override overlapping communication activity.