A computer-implemented method for providing increased scalability in deduplication storage systems may include (1) identifying a database that stores a plurality of reference objects, (2) determining that at least one size-related characteristic of the database has reached a predetermined threshold, (3) partitioning the database into a plurality of sub-databases capable of being updated independent of one another, (4) identifying a request to perform an update operation that updates one or more reference objects stored within at least one sub-database, and then (5) performing the update operation on less than all of the sub-databases to avoid processing costs associated with performing the update operation on all of the sub-databases. Various other systems, methods, and computer-readable media are also disclosed.