An interactive computerized game system including a visual display, one or more user input devices, and a processor executing software that interacts with the display and input device(s) is disclosed. The software displays images of musical targets on the visual display, the musical targets possibly corresponding to a pre-recorded source of music. At least one of the user input devices is a touchscreen arranged to simulate a portion of a musical instrument. During gameplay, the gameplayer must touch the touchscreen at the appropriate time and/or in the appropriate location in response to the displayed images of musical targets. The system provides a positive indication if the player's input matches the attributes of the displayed musical targets.