A system monitors and characterizes internal elasticity of a blood vessel to detect abnormality. A catheter system for heart performance characterization and abnormality detection, comprises an ultrasound device for emitting ultrasound wave signals within patient anatomy and acquiring corresponding ultrasound echo signals. A signal processor processes the ultrasound echo signals to, determine a signal indicating displacement of a tissue wall over at least one heart cycle and identify a displacement value in the displacement signal. The displacement value indicates a tissue wall displacement occurring at a point within a heart cycle. A comparator compares the tissue wall displacement value with a threshold value to provide a comparison indicator. A patient monitor, in response to the comparison indicator indicating the tissue wall displacement value exceeds the threshold value, generates an alert message associated with the threshold.