Invention Grant
- Patent Title: Agents for magnetic imaging method
- Patent Title (中): 磁成像方法代理
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Application No.: US12830067Application Date: 2010-07-02
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Publication No.: US08961927B2Publication Date: 2015-02-24
- Inventor: Silvio Aime , Valentina Mainero , Simonetta Chirich Geninatti , Claudia Cabella
- Applicant: Silvio Aime , Valentina Mainero , Simonetta Chirich Geninatti , Claudia Cabella
- Applicant Address: IT Milan
- Assignee: Bracco Imaging S.p.A.
- Current Assignee: Bracco Imaging S.p.A.
- Current Assignee Address: IT Milan
- Agent M. Caragh Noone
- Priority: EP02012531 20020605
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; C07C237/12 ; A61K41/00 ; A61K49/08 ; C07C237/10 ; C07C271/22 ; C07C279/12 ; C07C279/14

Abstract:
The invention provides MRI detectable species of formula (I) Dp-Sn-Nm (I) wherein D is a MRI detectable moiety S is a spacer N is a molecule of a nutrient or pseudo-nutrient n is 0 or an integer m is an integer and p is an integer. These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors.The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.
Public/Granted literature
- US20100311962A1 Agents For Magnetic Imaging Method Public/Granted day:2010-12-09
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