Invention Grant
- Patent Title: Micro-RNAS that control myosin expression and myofiber identity
- Patent Title (中): 控制肌球蛋白表达和肌纤维识别的微RNA
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Application No.: US13796884Application Date: 2013-03-12
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Publication No.: US08962588B2Publication Date: 2015-02-24
- Inventor: Eric N. Olson , Eva van Rooij
- Applicant: The Board of Regents, The University of Texas System
- Applicant Address: US TX Austin
- Assignee: The Board of Regents, The University of Texas System
- Current Assignee: The Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Cooley LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/02 ; C07H21/04
Abstract:
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
Public/Granted literature
- US20130245092A1 MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY Public/Granted day:2013-09-19
Information query
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