Invention Grant
US08962609B2 Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them
有权
嘧啶化合物作为蛋白激酶IKKε和/或TBK-1的抑制剂，其制备方法和含有它们的药物组合物
- Patent Title: Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them
- Patent Title (中): 嘧啶化合物作为蛋白激酶IKKε和/或TBK-1的抑制剂，其制备方法和含有它们的药物组合物
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Application No.: US13811164Application Date: 2011-07-18
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Publication No.: US08962609B2Publication Date: 2015-02-24
- Inventor: Trevor Robert Perrior , Gary Karl Newton , Mark Richard Stewart , Rehan Aqil
- Applicant: Trevor Robert Perrior , Gary Karl Newton , Mark Richard Stewart , Rehan Aqil
- Applicant Address: GB
- Assignee: Domainex Limited
- Current Assignee: Domainex Limited
- Current Assignee Address: GB
- Agency: Hahn Loeser & Parks LLP
- Priority: GB1012105.1 20100719
- International Application: PCT/GB2011/001075 WO 20110718
- International Announcement: WO2012/010826 WO 20120126
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/535 ; A61K31/497 ; A61K31/505 ; C07D401/12 ; C07D401/14 ; C07D413/14 ; C07D403/10 ; C07D417/10 ; C07D403/14 ; C07D239/42 ; C07D403/12 ; C07D417/14
Abstract:
C Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1: in which: R1 represents an aliphatic heterocyclyl group having 4, 5, 6 or 7 ring atoms, bonded to the phenyl group shown in formula I through a ring nitrogen atom, and optionally substituted by one or more substituents defined in the Specification; R2 represents a phenyl or heteroaryl group which is optionally substituted by one or more substituents defined in the Specification; and each of R3 and R4 independently represents a hydrogen atom or a C1-4 alkyl group.
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