Invention Grant
US08962618B2 Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
有权
二酰基甘油O-酰基转移酶1（DGAT-1）的抑制剂及其用途
- Patent Title: Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof
- Patent Title (中): 二酰基甘油O-酰基转移酶1（DGAT-1）的抑制剂及其用途
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Application No.: US13458452Application Date: 2012-04-27
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Publication No.: US08962618B2Publication Date: 2015-02-24
- Inventor: K. Raja Reddy , Jeff Stebbins , Serge H. Boyer , Mark D. Erion , Scott J. Hecker , Nicholas Brian Raffaele , Brett C. Bookser , Venkat Reddy Mali
- Applicant: K. Raja Reddy , Jeff Stebbins , Serge H. Boyer , Mark D. Erion , Scott J. Hecker , Nicholas Brian Raffaele , Brett C. Bookser , Venkat Reddy Mali
- Applicant Address: US CA La Jolla
- Assignee: Metabasis Therapeutics, Inc.
- Current Assignee: Metabasis Therapeutics, Inc.
- Current Assignee Address: US CA La Jolla
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Main IPC: A61K31/54
- IPC: A61K31/54 ; A61K31/535 ; C07D513/00 ; C07D265/36 ; C07D498/02 ; C07F9/6561 ; A61K31/52 ; A61K31/662 ; A61K31/665 ; A61K31/675 ; A61K45/06 ; C07D473/16 ; C07D473/34 ; C07D473/40 ; C07F9/30 ; C07F9/32 ; C07F9/653 ; C07F9/6574
Abstract:
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohdroxy pridines or primidines as diacylglycerol O-acyltransferase 1 DGAT-1 inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.
Public/Granted literature
- US20120270842A1 Inhibitors of Diacylglycerol O-Acyltransferase 1 (DGAT-1) and Uses Thereof Public/Granted day:2012-10-25
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