Invention Grant
US08962807B2 Single variable domain antibodies against OX40L, constructs and therapeutic use
有权
针对OX40L的单可变结构域抗体，构建体和治疗用途
- Patent Title: Single variable domain antibodies against OX40L, constructs and therapeutic use
- Patent Title (中): 针对OX40L的单可变结构域抗体，构建体和治疗用途
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Application No.: US13515876Application Date: 2010-12-14
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Publication No.: US08962807B2Publication Date: 2015-02-24
- Inventor: Frank Verdonck , Sigrid Cornelis , Stephanie Staelens
- Applicant: Frank Verdonck , Sigrid Cornelis , Stephanie Staelens
- Applicant Address: BE Zwijnaarde
- Assignee: Ablynx N.V.
- Current Assignee: Ablynx N.V.
- Current Assignee Address: BE Zwijnaarde
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/EP2010/069606 WO 20101214
- International Announcement: WO2011/073180 WO 20110623
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/00
Abstract:
The present invention relates to immunoglobulin single variable domain sequences that are directed against (as defined herein) OX40L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such immunoglobulin single variable domain sequences. In particular these immunoglobulin single variable domain sequences can block binding of OX40L to OX40. The immunoglobulin single variable domains, compounds and constructs can be used for prophylactic, therapeutic or diagnostic purposes, such as for the treatment of inflammatory disease and/or disorder such as e.g. asthma, allergic asthma, chronic colitis, Crohn's disease, inflammatory bowel disease, and/or arthrosclerosis.
Public/Granted literature
- US20130018175A1 SINGLE VARIABLE DOMAIN ANTIBODIES AGAINST OX40L, CONSTRUCTS AND THERAPEUTIC USE Public/Granted day:2013-01-17
Information query
