Invention Grant
US08962847B2 Multicomponent crystals made of ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and an arylpropionic acid 有权
由([2-氨基-6-(4-氟 - 苄基氨基) - 吡啶-3-基] - 氨基甲酸乙酯和芳基丙酸制成的多组分晶体

  • Patent Title: Multicomponent crystals made of ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and an arylpropionic acid
  • Patent Title (中): 由([2-氨基-6-(4-氟 - 苄基氨基) - 吡啶-3-基] - 氨基甲酸乙酯和芳基丙酸制成的多组分晶体
  • Application No.: US13992248
    Application Date: 2011-12-20
  • Publication No.: US08962847B2
    Publication Date: 2015-02-24
  • Inventor: Christoph Martin HoockAsal QadanBernd Terhaag
  • Applicant: Christoph Martin HoockAsal QadanBernd Terhaag
  • Applicant Address: DE Ulm
  • Assignee: TEVA GmbH
  • Current Assignee: TEVA GmbH
  • Current Assignee Address: DE Ulm
  • Agent Gudrun E. Huckett
  • Priority: DE102010063609 20101220
  • International Application: PCT/EP2011/073442 WO 20111220
  • International Announcement: WO2012/084976 WO 20120628
  • Main IPC: A61K31/44
  • IPC: A61K31/44 C07D213/75 A61K31/192
Multicomponent crystals made of ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester and an arylpropionic acid
Abstract:
The invention relates to novel multicomponent crystals, to the production thereof, and to the use thereof for treating pain conditions, in particular of unclear genesis, by means of a simultaneous effect on pains which are caused by muscle tension or degenerative joint diseases as well as on pains that are caused by inflammatory processes. The multicomponent crystals according to the invention contain ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester (flupirtine) and an arylpropionic acid as the sole active ingredient combination and can be produced by dissolving flupirtine and the arylpropionic acid in an inert organic solvent and subsequently crystallizing the multicomponent crystal.
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