Invention Grant
US08962887B2 Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
有权
在1-甲氧基-2-丙醇和水或甲醇中合成碘克沙醇
- Patent Title: Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
- Patent Title (中): 在1-甲氧基-2-丙醇和水或甲醇中合成碘克沙醇
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Application No.: US12621571Application Date: 2009-11-19
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Publication No.: US08962887B2Publication Date: 2015-02-24
- Inventor: Ole Magne Homestad
- Applicant: Ole Magne Homestad
- Applicant Address: NO Oslo
- Assignee: GE Healthcare AS
- Current Assignee: GE Healthcare AS
- Current Assignee Address: NO Oslo
- Main IPC: C07C233/64
- IPC: C07C233/64 ; C07C231/12
Abstract:
This invention relates to the synthesis of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide with a solvent mixture comprising 1-methoxy-2-propanol and water or methanol.
Public/Granted literature
- US20110021831A1 SYTNHESIS OF IODIXANOL IN 1-METHOXY-2-PROPANOL AND WATER OR METHANOL Public/Granted day:2011-01-27
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